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Article: "Brain MR spectroscopy in autism spectrum disorder-the GABA excitatory/inhibitory imbalance theory revisited".

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Brix MK; Ersland L; Hugdahl K; Grüner R; Posserud MB; Hammar Å; Craven AR; Noeske R; Evans CJ; Walker HB; Midtvedt T; Beyer MK
Front Hum Neurosci, 2015


The summarized results for the quantization of relevant metabolites from the MEGA-PRESS and PRESS sequences.

MEGA-PRESS ASD (n = 14) TD (n = 21) P-value
GABA+ 2.49 ± 0.40/2.53 2.66 ± 0.45/2.56 0.41
GABA+/Cr* 0.42 ± 0.066/0.42 0.44 ± 0.074/0.43 0.30
PRESS ASD (n = 14) TD (n = 24) P-value
Cr 6.01 ± 0.54/6.00 6.08 ± 0.39/6.05 0.71
NAA 8.61 ± 0.60/8.66 8.99 ± 0.73/9.08 0.10
MI 5.18 ± 0.87/5.08 4.98 ± 0.54/4.95 0.69
Cho 2.17 ± 0.21/2.16 2.19 ± 0.21/2.18 0.80
Glx 15.2 ± 1.58/15.00 15.49 ± 1.17/15.48 0.35

The concentrations obtained from the MEGA-PRESS experiment use water as an internal concentration reference. *Cr from PRESS. Data are presented as mean ± standard deviation/median. Values for metabolites are in Institutional Units.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source